Retinal Photoreceptor Degenerative Disease: Therapies and Their Challenges
Title: Retinal Photoreceptor Degenerative Disease: Therapies and Their Challenges
Author: Maureen McCall, PhD, Kentucky Lions Eye Research, University of Louisville
Keywords/Main Subjects:Animal model; RP; retinitis pigmentosa; P23H mini-swine model; rat; mouse; pig; photoreceptors; rods; cones; ERG; electrode; multielectrode array; gene therapy; rhodopsin; AAV; neuroprotection; rod-derived cone viability factor
Brief Description: A discussion of retinitis pigmentosa pathophysiology of the rods and cones, animal models used to study RP specifically focusing on a mini-swine model of P23H rhodopsin, the use of ERG and multielectrode arrays for evaluating photoreceptor function along with histology and OCT, plans for therapy for RP including gene supplementation and neuroprotection strategies, and initial animal models for delivery.
Series: Moran Eye Center Grand Rounds