Moran CORE

Open source ophthalmology education for students, residents, fellows, healthcare workers, and clinicians. Produced by the Moran Eye Center in partnership with the Eccles Library

Search Moran CORE

Simple Limbal Epithelial Transplantation (SLET) And Keratolimbal Allograft (KLAL) For Total LSCD After Alkali Injury

HomeExternal Disease and CorneaClinical Approach to Corneal Transplantation

Title: Simple Limbal Epithelial Transplantation (SLET) And Keratolimbal Allograft (KLAL) For Total LSCD After Alkali Injury

Authors: Colin S. Ip, M.D., Mark D. Mifflin M.D., University of Utah Health, John A. Moran Eye Center

Photographer: University of Utah Health, John A. Moran Eye Center

Date: 11/24/21

Keywords/Main Subjects: Simple Limbal Epithelial Transplantation (SLET), Keratolimbal allograft (KLAL), Limbal stem cell deficiency (LSCD), Alkali burn

Diagnosis: Limbal stem cell deficiency (LSCD)

Description of Case: Cornea with severe conjunctivalization from limbal stem cell deficiency after an alkali burn treated with SLET and KLAL.

Summary of the Case:

Alkali injuries to the eye can cause severe damage to the ocular surface and lead to limbal stem cell deficiency (LSCD). Long term consequences of LSCD include opacification, neovascularization, and conjunctivalization of the cornea, which results in poor vision. Treatment of this condition is complex and generally requires staged procedures to rehabilitate the cornea. Initial management includes restoring limbal stem cell function with an autogenic or allogenic transplant. Once LSCD is reversed, recurrence of neovascularization and conjunctivalization of the cornea should be limited and further intervention to clear the visual axis can be undertaken with penetrating keratoplasty, if indicated.

We present a case of complete LSCD accompanied by significant neovascularization and conjunctivalization of the cornea after a severe alkali injury that is treated with a combination of simple limbal epithelial transplant (SLET) and keratolimbal allograft (KLAL) transplantation.

Format: MP4

Faculty approval by: Mark D. Mifflin M.D.

Copyright: Colin Ip ©2022. For further information regarding the rights to this collection, please visit: http://morancore.utah.edu/terms-of-use/