Soluble FLT-1: From Wellspring of Avascularity to Springboard for Anti-Angiogenics
Title: Soluble FLT-1: From Wellspring of Avascularity to Springboard for Anti-Angiogenics
Author: Balamurali K. Ambati, PhD, MD
Keywords/Main Subjects: Angiogenesis; Soluble FLT-1; Anti-angiogenic therapy; Macular degeneration; Choriodal neovascularization; Vascular zoning; Nanoparticles; AMD;
Diagnosis: Age-related Macular Degeneration
Brief Description: This is a research presentation of the role of soluble FLT-1 in creating vascular demarcation zones in the retina. A mouse AMD model is presented as are techniques for blocking soluble FLT-1. Nanoparticles as a method of delivering possible novel anti-VEGF and anti-angiogenic factors are discussed.
Series: Moran Eye Center Grand Rounds