Integrated Analysis of Gene Expression, Genetics and Epigenetics
Title: Integrated Analysis of Gene Expression, Genetics and Epigenetics Suggests a Role for Lipid Metabolilsm in Involved in Age-Related Macular Deneneration
Author: Margaret DeAngelis, M.D., Ph.D, Associate Professor of Ophthalmology and Visual Sciences
Keywords/Main Subjects: Polygenic; Multifactorial Inheritance; Genetic disease; Genome; ARMD; Whole exome sequencing; Epigentics; ABCA1
Secondary CORE Category: Principles of Ophthalmology/ Clinical Genetics / Complex Genetic Disease: Polygenic and Multifactorial Inheritance
Brief Description: This is a research presentation on the use of SNPs and genomics to determine genes associated with ARMD. In particular, ABCA1, a cholesterol efflux pum protein in the statin pathway, is discussed as a gene important in ARMD risk.
Series: Moran Eye Center Grand Rounds